The Mesothelioma

The Mesothelioma is a tumor of the mesothelium (from the mesenchyme derived polygonal squamous serous membranes ). Most commonly it is found in the pleura , the pericardium and the peritoneum and the tunica vaginalis .(Dallas mesothelioma attorneys)

2 Epidemiology

The slow-growing benign mesothelioma occurs in comparison to malignant rather rare on variant. Men are affected more often than women.

3 etiology

The most important factor in the development of malignant mesothelioma is asbestos exposure considered. The latency period after exposure to asbestos is long and is to occur first symptoms ca. Is 33 years.(Top Dallas mesothelioma attorneys)

Furthermore, can be an association with infection with the simian virus watching 40 (SV40).

In molecular pathological level, an elevated place prevalence of mesothelioma in losses on chromosomes 1p, 1q, 4p, 4q, 8q, 9p, 14q, 22q and in inactivation of tumor suppressor genes RASSF1 and MLH1 and upon activation of the oncogene c-Myc .

4 Pathology

4.1 Morphology
Depending on the morphological type of growth and differentiation can be characterized mesothelioma. Mixed types are relatively common, with different degrees of differentiation differentiations and can be very close to each other or even on the same tumor area.
Malignant mesothelioma is the one to be extremely rare, localized fibrous variant, on the other hand as a diffuse variant before.

4.2.1 Lokalisiertes fibröses mesothelioma
The structure is very similar to the benign mesothelioma which cells but grow infiltrative . Histologically dominated by collagen fibers marbled, spindle-shaped sarcoma cells .mesothelioma)

4.2.2 Diffuse Mesothelioma
The diffuse mesothelioma comes as most mesothelioma before. First, multiple, relatively small form nodules which later however large tumor boards coalesce. This then grows around the lungs and infiltrate the Interlobärspalten.

The diffuse pleural mesothelioma metastasizes frequently, preferably in the contralateral pleura and lung , as well as in thoracic lymph nodes .(mesothelioma attorneys)

5 symptoms

The most common symptom is recurrent pleural - pericardium - or Peritonealergüsse which might occur long before the diagnosis. Later symptoms occur as local pain and weight loss added.

6 therapy

Where possible, the mesothelioma is surgically removed and then adjuvant radiotherapy and chemo therapy. Important is a radiation of the operating channel and the surgical wound, since the Mesotheliomgewebe preferably grows into it.